My daugher, 17, has severe PMDD (hospitalized twice for being suicidal and once for attemting). Tried many SSRIs for years and none worked, made her far worse in fact. she's too young to take SSRI's. Too risky at her age.

Sam-e, 1,000mg per day, has made a huge difference but she still dips a couple of days before she starts and feels better about 24 after she starts.