Its safe about 7 days after your GF starts the pill to start having unprotected sex.
I am not sure if diff pills have different amounts of time but I think its usually about 7 days before the hormone is in the body properly.
If your GF was interested there is a thing called the Mirena Coil- Dr needs to 'put it in' though, but it works immediatley, literally if you wanted to have sex that evening you are protected immediatley (apparently!)
It also the most effective contraception available(besides tubes being tied) ....Might be worth a think for the future...(not sure if you need have had a baby before getting this)Check with your chemist maybe to see what they recommend....
HTH




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