Ovarian Cancer: Not So Silent?
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By Christine Haran
Doctors and cancer advocates have traditionally been at a loss when it comes to making recommendations to women for the early detection of ovarian cancer. Not only is there no effective screening tool for ovarian cancer, it is not associated with any signature symptom. As a result, ovarian cancer is often called "the silent cancer."
Yet this cancer has a major impact on women. Every year, approximately 23,000 women in the United States are diagnosed with ovarian cancer and 14,000 die of the disease, making it the fifth leading cause of cancer death for women. Detection at an earlier stage of the disease would help more women live longer: While the five-year survival rates for early-stage ovarian cancer are between 70 and 90 percent, they drop to 20 to 30 percent for women with advanced-stage ovarian cancer.
A new study, published in the June 9th issue of the Journal of the American Medical Association, suggests ovarian cancer does hint at its presence in the body. The researchers, led by Barbara A. Goff, MD, of the University of Washington School of Medicine in Seattle, found that 95 percent of the participants with ovarian cancer reported symptoms before their diagnoses, including back pain, fatigue, bloating, constipation, abdominal pain and a feeling that they had to urinate urgently. Below, Mary Daly, MD, PhD, director of cancer prevention and control at Fox Chase Cancer Center in Philadelphia, discusses the study and the importance of weighing these symptoms in context of a woman's individual circumstances.
Why is ovarian cancer usually diagnosed in its advanced stages?
That's a question that I don't think we have an answer to. The traditional thinking has been because it doesn't produce obvious, recognizable symptoms. In contrast, gastrointestinal (GI) bleeding can be a recognizable symptom of colon cancer. So an ovarian cancer grows to an advanced stage before it's diagnosed. The other theory has been that it just grows so rapidly that there is a very short period of time when it's at an early stage. We still don't really know which of those two theories are true.
Why isn't routine screening for ovarian cancer recommended?
The existing tests, which are primarily ultrasound and a blood test called CA-125, have been studied in a variety of different settings but they haven't been accurate enough in early diagnosis of ovarian cancer to be used as a screening test for everyone. They have the problem of missing ovarian cancers, or on the other hand, being positive when there is no ovarian cancer. So their accuracy is too inadequate to make them useful as general screening tools.
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