NO, it is not possible to build muscle over fat. Muscle weighs more than fat, so as you tone and become leaner that does not mean that you will necessarily "lose weight".
A combination of cardio and free weight training is very good. I hesitate to say what is "best" because then I'm nothing more than a late night infomercial...
One thing I might suggest is doing cardio X number of days each week and doing free weight training X number of days per week. Like cardio on M, W, F and free weights on T, Th. When using free weights think low to moderate weight and high repititions per set (12 -15) and do two or three sets of each exercise before moving on to the next one.
As for cardio, mix it up between treadmill, stairmaster, eliptical, upright bike, recumbant bike.
Is there a rowing machine at your fitness center or gym where you exercise? If there is, I strongly recommend that you learn how to use it and use it properly. 18 muscles are used in rowing and it includes all areas of the body....shoulders, arms, chest, abs/core, back, butt, thighs and calves....with one piece of equipment.
Obviously, calories is the biggest issue. Take in more calories than you burn = weight gain. Burn more calories than you take in = weight loss.
The most imprtant things in any exercise routine are (in order of importance) 1) Fuel - the foods you eat, 2) Form - the technique used to do any single exercise, and 3) Weight - the amount of weight or resistence used to work the muscles.




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I'm Australian, but if you can eat tuna, then pack a lunch box with cut celery, cucumber, lettuce, cherry tomatoes and add a can of tuna. 


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