Do you have any peeling skin associated with it? Do you have athlete's foot? I know that athlete's foot can drive me mad sometimes, I've had it all my life. It got under my toe nails and became so infected that I don't even have toe nails anymore. I've found creams and lotions to be useless too, but if what you have is athlete's foot related, I know that moisture and heat are the worst for it. Keep them dry and exposed to open air whenever possibe (I have to wear open-toed shoes almost all year round, or else they get extremely irritated if they get sweaty and hot.) Keeping them cold is good, it seems to be the only thing that helps me.