I am 33yrs old and classified as obese. In Jan 09 I was diagnosed with simple hyperplasia without atypia after bleeding heavily for over 2 weeks. I had a biopsy which diagnosed this and was put on megace to stop the bleeding and a few weeks later an ultrasound showed my uterus was very very think (I believe 30mm)so my doctor then called and said I had to have a D&C. I was happy to do this, the sooner the better as the side effects from the megace turned me into a moody monster. I had the D&C and was advised to continue the megace for another month then had another biopsy to confirm all was now normal. I was so happy to hear that! I went on progesterone only contraceptive pill (I have history of stroke as child) and thought all was well. After 8 months we decided to start a family and with the advice of my fertility doc stopped the pill while we diagnosed my infertility as PCOS and I started Metformin. Now 5 months since stopping the pill I have just started very heavy bleeding and it seems the hyperplasia is back (ultrasound this weeks suggests this) and I am due for a biopsy this week to confirm. I am so down about it and assume the PCOS and hyperplasia go together for me like a chicken and the egg!!!!! I hope they will do a D&C again to lessen the time on the megace but I am not sure as I am also on Coumadin until Dec 2010 for a recent closing of a hole in my heart (also diagnosed during the infertility work ups!), so maybe they won't operate while I am on blood thinners. I was also told this week that I have hypoglycemia too and so need to follow a food plan to control this (and it would improve the PCOS possibly too.) Has anyone else experienced anything similar on any of these issues?