Nah, once its inside me I don't notice any difference at all as far as pleasure goes, its the same. The girls I know that don't like condoms its because of the stopping to put them on, and the intimacy factor on a mental level... feeling close without the plastic sack between them.. and some will say they like the feeling of the ejaculate... but for the actual penetration part... feels same.
I think there are other ways to share that intimacy without a condom while still using the condom for penetrative intercourse.
I've known girls that will risk their health to go without a condom with a guy just to prove they trust them, and some girls that want their guy to have sex without a condom as an indication that they wouldn't mind them having a baby, or that they think they are clean etc...
Condoms are what they are and its foolish to not use them outside of totally committed relationships.