Weight lifting improves your bone density (prevent osteoperosis, stress injuries) and muscle tone (feel better, fewer aches and pains). It also increases muscle mass, which helps you burn more calories at rest and when working out. The "2-3 rule" of weights is that you can get 85% of the above benefits by doing resistance work 2-3 days per week.
Cardio strengthens your heart muscle, which lowers your resting heart rate (leading to fewer pumps per day, and thus extending your heart's lifetime), increases good cholesterol, and also burns calories. Aerobic workouts (where your pulse is at 65-85% of your max HR) don't build muscle though. So, by combining your cardio with weights, you increase the number of ways to lose weight. The 2-3 rule applies to cardio workouts (85% of the benefits from 2-3 days of workouts, with 20-30 minutes spent in your aerobic HR range)
There's also flexibility--doesn't burn many calories, but it loosens your tight muscles and prevents you getting sidelined from a workout-related injury.
Also, keep in mind that reducing your calories eaten has the exact same effect as increasing your calories burned. By cutting just a few hundred calories from your daily diet, you won't have to spend so much time on the cardio machines. 45 minutes daily is probably more than your heart actually needs to be healthy. So temporary diet adjustments can take some of the weight loss burden off of your workouts.
Hope that helps--I'm trying to lose 2 lbs/wk myself on diet and exercise--
Best wishes!




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