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What might be the cause of high estrogen and low T and progesterone in a 27 year old?

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  • What might be the cause of high estrogen and low T and progesterone in a 27 year old?

    I should be clear that only my testosterone is actually outside the normal range. My progesterone is only borderline low and my estrogen is borderline high. My ratio of progesterone to estradiol is also very low. Here are the actual numbers:
    Estradiol 3.3 pg/ml (Above 3.3 is excessive)
    Progesterone 76 pg/ml (Below 75 is deficient)
    Testosterone 12 ng/dl (Below 20 is deficient)
    Pg/E2 ratio is 23 (Below 100 is considered imbalanced)

    What might be causing this kind of imbalance in someone my age?

  • Anybody?


    • Hi and Welcome to the forum.
      I'm sorry no one has responded as of yet, there are people from around the World on this Forum, many with different time zones. So it may take time to answer or get any Advice.

      I see that there have been 96 views, but no ones answered. This may be because none of us ( That i know of )are are are are not Privy to the schooling that Dr's have and many of us are unwilling to " Diagnose " your problem .
      But I am one that tries to help , even on a subject I don't know much about And I usually learn a great deal by researching the posters problem and trying to get some Simpler reasons for it . I usually use Google and sometimes will post General Info to help until they can do the research themselves or see their DR .

      I am assuming you or your SO is Male, therefore the concern on the Low Testosterone ?

      I did a Simple Search and used the words " What causes High Estrogen and Low T " and this is just some of what I came up with..
      It is long and only 1/4 of the page ( site page ).

      Eugene Shippen, M.D., authored a book in 1998 called The Testosterone Syndrome. He was a speaker at the American Academy of Anti-Aging Medicine Conference held in December 1998, where he provided extensive evidence documenting the pathology of the testosterone deficiency syndrome in men. Here are some excerpts from Dr. Shippen's presentation:

      "First, Testosterone is not just a "sex hormone." It should be seen as a "total body hormone," affecting every cell in the body. The changes seen in aging, such as the loss of lean body mass, the decline in energy, strength, and stamina, unexplained depression, and decrease in sexual sensation and performance, are all directly related to testosterone deficiency. Degenerative diseases such as heart disease, stroke, diabetes, arthritis, osteoporosis, and hypertension are all directly or indirectly linked to testosterone decline. Secondly, testosterone also functions as a prohormone. Local tissue conversion to estrogens, dihydrotestosterone (DHT), and other tissue metabolites plays an important part in cellular physiology.

      Excess estrogen seems to be the culprit in prostate enlargement. Low testosterone levels are in fact associated with more aggressive prostate cancer. While fear of prostate cancer keeps many men from testosterone replacement, it is in fact testosterone deficiency that leads to the pathology that favors the development of prostate cancer.

      Testosterone improves cellular bioenergetics. It acts as a cellular energizer. Since testosterone increases the metabolic rate and aerobic metabolism, it also dramatically improves glucose metabolism and lowers insulin resistance.

      Another myth is that testosterone is bad for the heart. Actually, low testosterone correlates with heart disease more reliably than does high cholesterol. Testosterone is the most powerful cardiovascular protector for men. Testosterone strengthens the heart muscle; there are more testosterone receptors in the heart than in any other muscle. Testosterone lowers LDL cholesterol and total cholesterol, and improves every cardiac risk factor. It has been shown to improve or eliminate arrhythmia and angina. "Testosterone replacement is the most underutilized important treatment for heart disease."

      Testosterone shines as a blood thinner, preventing blood clots. Testosterone also helps prevent colon cancer.

      Previous research on testosterone used the wrong form of replacement. Injections result in initial excess of testosterone, with conversion of excess to estrogens. Likewise, total testosterone is often measured instead of free testosterone, the bioavailable form. Some studies do not last long enough to show improvement. For instance, it may take six months to a year before the genital tissue fully recovers from atrophy caused by testosterone deficiency, and potency is restored.

      Physicians urgently need to be educated about the benefits of testosterone and the delicate balance between androgens (testosterone) and estrogens. Each individual has his or her own pattern of hormone balance; this indicates that hormone replacement should be individualized and carefully monitored."

      Dr. Shippen's book, The Testosterone Syndrome, provides a persuasive argument in favor of hormone modulation in the aged male, and contains many interesting case histories. Dr. Wright's and Dr. Ullis's books on this subject are also available.

      Obesity and Hormone Imbalance

      A consistent finding in the scientific literature is that obese men have low testosterone and very high estrogen levels. Central or visceral obesity (pot belly) is recognized as a risk factor for cardiovascular disease and type II diabetes. New findings have shed light on subtle hormone imbalances of borderline character in obese men and often fall within the normal laboratory reference range. Boosting testosterone levels seems to decrease the abdominal fat mass, reverse glucose intolerance, and reduce lipoprotein abnormalities in the serum. Further analysis has also disclosed a regulatory role for testosterone in counteracting visceral fat accumulation. Longitudinal epidemiological data demonstrate that relatively low testosterone levels are a risk factor for development of visceral obesity.

      One study showed that serum estrone and estradiol were elevated twofold in one group of morbidly obese men. Fat cells synthesize the aromatase enzyme, causing male hormones to convert to estrogens. Fat tissues, especially in the abdomen, have been shown to literally "aromatize" testosterone and its precursor hormones into potent estrogens.

      Eating high-fat foods may reduce free testosterone levels according to one study that measured serum levels of sex steroid hormones after ingestion of different types of food. High-protein and high-carbohydrate meals had no effect on serum hormone levels, but a fat-containing meal reduced free testosterone levels soci4 hours.

      Obese men suffer from testosterone deficiency caused by the production of excess aromatase enzyme in fat cells and also from the fat they consume in their diet. The resulting hormone imbalance (too much estrogen and not enough free testosterone) in obese men partially explains why so many are impotent, and suffer from a wide range of premature degenerative diseases.

      Factors Causing the Estrogen-Testosterone Imbalance in Men

      If your blood tests reveal high estrogen and low testosterone, here are the common factors involved:

      Excess "aromatase" enzyme. As men age, they produce larger quantities of an enzyme called aromatase. The aromatase enzyme converts testosterone into estrogen in the body. Inhibiting the aromatase enzyme results in a significant decline in estrogen levels while often boosting free testosterone to youthful levels. Therefore, an agent designated as an "aromatase inhibitor" may be of special value to aging men who have excess estrogen.

      Liver enzymatic activity. A healthy liver eliminates surplus estrogen and sex hormone-binding globulin. Aging, alcohol, and certain drugs impair liver functionand can be a major cause of hormone imbalance in aging men. Heavy alcohol intake increases estrogen in men and women.

      Obesity. Fat cells create aromatase enzyme and especially contribute to the buildup of abdominal fat. Low testosterone allows the formation of abdominal fat, which then causes more aromatase enzyme formation and thus even lower levels of testosterone and higher estrogen (by aromatizing testosterone into estrogen). It is especially important for overweight men to consider hormone modulation therapy.

      Zinc deficiency. Zinc is a natural aromatase enzyme inhibitor. Since most people do not consume adequate amounts of zinc (30 to 90 mg a day).

      Lifestyle changes (such as reducing alcohol intake) can produce a dramatic improvement in the testosterone-estrogen balance, but many people need to use aromatase-inhibiting agents to lower estrogen and to improve their liver function to remove excess SHBG. Aromtase converts testosterone into estrogen and can indirectly increase SHBG. SHBG binds to free testosterone and prevents it from exerting its biochemical effects in the body.

      This is simply a tiny part of the things that can cause what you are asking about.

      So allot depends on , It seems , Age, Diet, General Health, Weight, Glands and so on .
      I would hate for someone, including myself, to offer Advise that could harm you if you followed it ..
      But you can do some research on your own and determine if you need to see a Specialist .
      If you have seen one, make another appointment and ask Questions, Specific Questions, Take note on what you find out through Research like I just did and have Specific questions on the list .

      Make your DR. speak With you not At or To you .. Your Dr. should be your Partner in Health.
      Good Luck .


      • I'm female and those are my own results. Deficient testosterone is a concern for women and not just men, although I know that what constitutes low T obviously varies a huge amount between the sexes. Because I'm young(ish), female, and not obese, it's hard to say what applies to me from the article above. Many things that have a certain hormonal effect in males have a very different (or even opposite) effect in females. The same goes for young vs old, or obese vs normal weight.

        Does anyone have any other ideas about what might be causing this. It seems somewhat possible that it all might be happening just because I'm completely out of shape. I AM noticeably chubby, but I'm 5'4 125 lb, so I'm far, far away from morbid obesity. Does anyone have any idea if it make sense to think that that my hormones could be this far off kilter just from slight chubbiness and lack of exercise? I think I might look into how lack of exercise and or "overfatness" effects testosterone levels in women. Does anyone know more about that? Obese women typically have the opposite problem (very high testosterone) but they are usually insulin resistant and I am probably not.
        Last edited by Mochaccino; 02-03-2013, 03:30 PM.


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